Difference between revisions of "Ivermectin has beneficial effects against SARS-COV-2"

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(Created page with "'''Ivermectin has beneficial effects against SARS-COV-2''' is an argument derived from over 76 independent studies conducted by researchers around the world showing an unambiguous medical benefit in the treatment of patients suffering from SARS-COV-2 infection and the resultant Covid-19 disease. '''Reasons & Support''' @namespace svg url(http://www.w3.org/2000/svg); svg|a { color:#606060; /\* lc \*/ fill:#606060; /\* lc \*/ } svg|a:visited { color:#606060; /\* lc \*/ f...")
 
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'''Reasons & Support'''  
'''Reasons & Support'''  
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1) Statistically significant improvements are seen for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance. All remain significant after exclusions. 49 studies from 45 independent teams in 21 different countries show statistically significant improvements in isolation (37 primary outcome, 34 most serious outcome).


•Statistically significant improvements are seen for [mortality](#fig_fpd), [ventilation](#fig_fpm), [ICU admission](#fig_fpi), [hospitalization](#fig_fph), [recovery](#fig_fpry), [cases](#fig_fpc), and [viral clearance](#fig_fpv). All remain significant after [exclusions](https://ivmmeta.com/supp.html). 49 studies from 45 independent teams in 21 different countries show statistically significant improvements in isolation (37 primary outcome, 34 most serious outcome).
2) Meta analysis using the most serious outcome shows 66% [53‑75%] and 83% [74‑89%] improvement for early treatment and prophylaxis, with similar results after exclusion based sensitivity analysis (excluding all GMK/BBC team studies), for primary outcomes, for peer-reviewed studies, and for RCTs.


•Meta analysis using the most serious outcome shows 66% \[53‑75%\] and 83% \[74‑89%\] improvement for [early treatment and prophylaxis](#fig_fpep), with similar results after [exclusion based sensitivity analysis](#fig_fpe) (excluding all GMK/BBC team studies), for [primary outcomes](https://ivmmeta.com/supp.html), for [peer-reviewed studies](#fig_fpp), and for [RCTs](#fig_fpr).
3) Results are very robust — in worst case exclusion sensitivity analysis 60 of 76 studies must be excluded to avoid finding statistically significant efficacy.


•Results are very robust — in worst case exclusion sensitivity analysis 60 of 76 studies must be excluded to avoid finding statistically significant efficacy.
<table class="tables">
<tbody><tr><td>Results</td><td class="h350"><i>Studies</i></td>
  <td><i><a class="metal" href="#fig_fp">Prophylaxis</a></i></td>
  <td><i><a class="metal" href="#fig_fp">Early treatment</a></i></td>
  <td><i><a class="metal" href="#fig_fp">Late treatment</a></i></td>
  <td class="h375"><i>Patients<i></i></i></td><td class="h450"><i>Authors<i></i></i></td></tr>


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<tr><td><a class="metal" href="#fig_fp">All studies</a></td>
<td class="h350">76</td>
<td><b>83%</b>&nbsp;<span class="rrcls">[74‑89%]</span></td>
<td><b>66%</b>&nbsp;<span class="rrcls">[53‑75%]</span></td>
<td><b>39%</b>&nbsp;<span class="rrcls">[23‑52%]</span></td>
<td class="h375">57,647</td>
<td class="h450">718</td>


•While [many treatments](https://c19early.com/) have some level of efficacy, they do not replace vaccines and other measures to avoid infection. Only 25% of ivermectin studies show zero events in the treatment arm.


[Multiple treatments](https://c19early.com/) are typically used in combination, which may be significantly more effective.
</tr><tr><td><span class="desktop"><a class="metal" href="#fig_fpp">Peer-reviewed</a></span><span class="mobile"><a class="metal" href="#fig_fpp">Peer-reviewed</a></span></td>
<td class="h350">55</td>
<td><b>83%</b>&nbsp;<span class="rrcls">[73‑90%]</span></td>
<td><b>68%</b>&nbsp;<span class="rrcls">[50‑80%]</span></td>
<td><b>41%</b>&nbsp;<span class="rrcls">[17‑58%]</span></td>
<td class="h375">25,228</td>
<td class="h450">558</td>


•Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all variants. All practical, effective, and safe means should be used, including treatments, as supported by Pfizer \[[Pfizer](#ref_pfizerq22021), [TrialSiteNews](#ref_trialsitepfizer)\]. Denying the efficacy of treatments increases mortality, morbidity, collateral damage, and endemic risk.


_Studies_
</tr><tr><td><span class="desktop"><a class="metal" href="#bbc">With GMK/BBC exclusions</a></span><span class="mobile"><a class="metal" href="#bbc">w/GMK/BBC exclusions</a></span></td>
<td class="h350">51</td>
<td><b>82%</b>&nbsp;<span class="rrcls">[68‑89%]</span></td>
<td><b>73%</b>&nbsp;<span class="rrcls">[64‑80%]</span></td>
<td><b>53%</b>&nbsp;<span class="rrcls">[29‑69%]</span></td>
<td class="h375">44,741</td>
<td class="h450">545</td>


_[Prophylaxis](#fig_fp)_


_[Early treatment](#fig_fp)_
</tr><tr><td><span class="desktop"><a class="metal" href="#fig_fpr">Randomized Controlled Trials</a></span><span class="mobile"><a class="metal" href="#fig_fpr">RCTs</a></span></td>
<td class="h350">32</td>
<td><b>84%</b>&nbsp;<span class="rrcls">[25‑96%]</span></td>
<td><b>62%</b>&nbsp;<span class="rrcls">[45‑74%]</span></td>
<td><b>23%</b>&nbsp;<span class="rrcls">[-1‑41%]</span></td>
<td class="h375">7,032</td>
<td class="h450">361</td>


_[Late treatment](#fig_fp)_


_Patients_
</tr><tr><td><span class="desktop"><a class="metal" href="/supp.html#fig_fpre">RCTs w/GMK/BBC exclusions</a></span><span class="mobile"><a class="metal" href="/supp.html#fig_fpre">RCTs w/GMK/BBC exc.</a></span></td>
<td class="h350">25</td>
<td><b>84%</b>&nbsp;<span class="rrcls">[25‑96%]</span></td>
<td><b>69%</b>&nbsp;<span class="rrcls">[56‑77%]</span></td>
<td><b>26%</b>&nbsp;<span class="rrcls">[-2‑46%]</span></td>
<td class="h375">4,423</td>
<td class="h450">299</td>


_Authors_
</tr><tr class="nob"><td class="nob" colspan="7"><i>Percentage improvement with ivermectin treatment</i></td></tr>
 
</tbody></table>
[All studies](#fig_fp)
 
76
 
**83%** \[74‑89%\]
 
**66%** \[53‑75%\]
 
**39%** \[23‑52%\]
 
57,647
 
718
 
[Peer-reviewed](#fig_fpp)[Peer-reviewed](#fig_fpp)
 
55
 
**83%** \[73‑90%\]
 
**68%** \[50‑80%\]
 
**41%** \[17‑58%\]
 
25,228
 
558
 
[With GMK/BBC exclusions](#bbc)[w/GMK/BBC exclusions](#bbc)
 
51
 
**82%** \[68‑89%\]
 
**73%** \[64‑80%\]
 
**53%** \[29‑69%\]
 
44,741
 
545
 
[Randomized Controlled Trials](#fig_fpr)[RCTs](#fig_fpr)
 
32
 
**84%** \[25‑96%\]
 
**62%** \[45‑74%\]
 
**23%** \[-1‑41%\]
 
7,032
 
361
 
[RCTs w/GMK/BBC exclusions](/supp.html#fig_fpre)[RCTs w/GMK/BBC exc.](/supp.html#fig_fpre)
 
25
 
**84%** \[25‑96%\]
 
**69%** \[56‑77%\]
 
**26%** \[-2‑46%\]
 
4,423
 
299
 
_Percentage improvement with ivermectin treatment_
 
•There is evidence of a negative publication bias, and the probability that an ineffective treatment generated results as positive as the 76 studies is estimated to be 1 in 68 billion.
 
•[Over 20 countries](https://ivmstatus.com/) have adopted ivermectin for COVID-19. The evidence base is [much larger](#table_whoapproval) and has much lower conflict of interest than typically used to approve drugs.
 
•All data to reproduce this paper and sources are in the [appendix](#appendix_methods). See \[[Bryant](#ref_bryant), [Hariyanto](#ref_hariyanto2), [Kory](#ref_kory3), [Lawrie](#ref_lawrie), [Nardelli](#ref_nardelli)\] for other meta analyses with similar results confirming efficacy.
 
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[Global adoption: 37%](https://ivmstatus.com/)
 
[![](plot/ivmworld.svg)](https://ivmstatus.com/)
 
_Evidence base used for other COVID-19 approvals_
 
Medication
 
Studies
 
Patients
 
Improvement
 
[Molnupiravir (UK)](https://www.gov.uk/government/news/first-oral-antiviral-for-covid-19-lagevrio-molnupiravir-approved-by-mhra)
 
1
 
775
 
50%
 
[Budesonide (UK)](https://www.england.nhs.uk/coronavirus/wp-content/uploads/sites/52/2021/04/C1253-interim-position-statement-inhaled-budesonide-for-adults.pdf)
 
1
 
1,779
 
17%
 
[Remdesivir (USA EUA)](https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-issues-emergency-use-authorization-potential-covid-19-treatment)
 
1
 
1,063
 
31%
 
[Casirivimab/i.. (USA EUA)](https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-monoclonal-antibodies-treatment-covid-19)
 
1
 
799
 
66%
 
_Ivermectin evidence_
 
76
 
57,623
 
65% \[57‑72%\]


{{Claim
{{Claim
Line 175: Line 73:
==References==
==References==
<references/>
<references/>
ivmmeta.com
[[https://ivmmeta.com/ ivmmeta.com]]
[[Category:Biology and Medicine]]
[[Category:Biology and Medicine]]

Revision as of 23:49, 22 January 2022

Ivermectin has beneficial effects against SARS-COV-2 is an argument derived from over 76 independent studies conducted by researchers around the world showing an unambiguous medical benefit in the treatment of patients suffering from SARS-COV-2 infection and the resultant Covid-19 disease.

Reasons & Support 1) Statistically significant improvements are seen for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance. All remain significant after exclusions. 49 studies from 45 independent teams in 21 different countries show statistically significant improvements in isolation (37 primary outcome, 34 most serious outcome).

2) Meta analysis using the most serious outcome shows 66% [53‑75%] and 83% [74‑89%] improvement for early treatment and prophylaxis, with similar results after exclusion based sensitivity analysis (excluding all GMK/BBC team studies), for primary outcomes, for peer-reviewed studies, and for RCTs.

3) Results are very robust — in worst case exclusion sensitivity analysis 60 of 76 studies must be excluded to avoid finding statistically significant efficacy.

<tbody>





</tbody>
ResultsStudies <a class="metal" href="#fig_fp">Prophylaxis</a> <a class="metal" href="#fig_fp">Early treatment</a> <a class="metal" href="#fig_fp">Late treatment</a> PatientsAuthors
<a class="metal" href="#fig_fp">All studies</a> 76 83% [74‑89%] 66% [53‑75%] 39% [23‑52%] 57,647 718
<a class="metal" href="#fig_fpp">Peer-reviewed</a><a class="metal" href="#fig_fpp">Peer-reviewed</a> 55 83% [73‑90%] 68% [50‑80%] 41% [17‑58%] 25,228 558
<a class="metal" href="#bbc">With GMK/BBC exclusions</a><a class="metal" href="#bbc">w/GMK/BBC exclusions</a> 51 82% [68‑89%] 73% [64‑80%] 53% [29‑69%] 44,741 545
<a class="metal" href="#fig_fpr">Randomized Controlled Trials</a><a class="metal" href="#fig_fpr">RCTs</a> 32 84% [25‑96%] 62% [45‑74%] 23% [-1‑41%] 7,032 361
<a class="metal" href="/supp.html#fig_fpre">RCTs w/GMK/BBC exclusions</a><a class="metal" href="/supp.html#fig_fpre">RCTs w/GMK/BBC exc.</a> 25 84% [25‑96%] 69% [56‑77%] 26% [-2‑46%] 4,423 299
Percentage improvement with ivermectin treatment
Claim
Statement of the claim Ivermectin has beneficial effects against SARS-COV-2
Level of certainty True
Nature Factual
Counterclaim Ivermectin has no effect or detrimental effects against SARS-COV-2
Dependent on

Definition:SARS-COV-2

Dependency of


References

[ivmmeta.com]